Analysis of protein–protein interactions by mutagenesis: direct versus indirect effects
نویسندگان
چکیده
منابع مشابه
1 “ Distinguishing direct versus indirect transcription factor - DNA interactions ”
P<P Published online August 3, 2009 in advance of the print journal. Open Access This manuscript is Open Access. Preprint Accepted likely to differ from the final, published version. Peer-reviewed and accepted for publication but not copyedited or typeset; preprint is service Email alerting click here top right corner of the article or Receive free email alerts when new articles cite this artic...
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Transcriptional regulation is largely enacted by transcription factors (TFs) binding DNA. Large numbers of TF binding motifs have been revealed by ChIP-chip experiments followed by computational DNA motif discovery. However, the success of motif discovery algorithms has been limited when applied to sequences bound in vivo (such as those identified by ChIP-chip) because the observed TF-DNA inter...
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The direct effect of one event on another can be defined and measured by holding constant all intermediate variables between the two. Indirect effects present conceptual and prac tical difficulties (in nonlinear models), be cause they cannot be isolated by holding cer tain variables constant. This paper presents a new way of defining the effect transmit ted through a restricted set of paths...
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Phenobarbital (PB) treatment impairs the biliary excretion of some organic anions. One mechanism may involve direct competition for biliary excretion by PB and/or a PB metabolite. Alternatively, PB may alter the expression and/or function of hepatic organic anion transport proteins. The role of multidrug resistance-associated protein 2 (Mrp2) in the biliary excretion of PB and metabolites was s...
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Mediation analysis, or more generally models with direct and indirect effects, are commonly used in the behavioral sciences. As we show in our illustrative example, traditional methods of mediation analysis that omit confounding variables can lead to systematically biased direct and indirect effects, even in the context of a randomized experiment. Therefore, several definitions of causal effect...
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ژورنال
عنوان ژورنال: Protein Engineering, Design and Selection
سال: 1999
ISSN: 1741-0134,1741-0126
DOI: 10.1093/protein/12.1.41